Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser(863) and Multisite Phosphorylation

The rapamycin-sensitive mTOR complex 1 (mTORC1) promotes protein synthesis, cell growth, and cell proliferation in response to growth factors and nutritional cues. To elucidate the poorly defined mechanisms underlying mTORC1 regulation, we have studied the phosphorylation of raptor, an mTOR-interact...

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Bibliographische Detailangaben
Hauptverfasser: Foster, Kathryn G., Acosta-Jaquez, Hugo A., Romeo, Yves, Ekim, Bilgen, Soliman, Ghada A., Carriere, Audrey, Roux, Philippe P., Ballif, Bryan A., Fingar, Diane C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Mechanisms of Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804229/
https://ncbi.nlm.nih.gov/pubmed/19864431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.029637
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