Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser(863) and Multisite Phosphorylation

The rapamycin-sensitive mTOR complex 1 (mTORC1) promotes protein synthesis, cell growth, and cell proliferation in response to growth factors and nutritional cues. To elucidate the poorly defined mechanisms underlying mTORC1 regulation, we have studied the phosphorylation of raptor, an mTOR-interact...

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Bibliografiske detaljer
Main Authors: Foster, Kathryn G., Acosta-Jaquez, Hugo A., Romeo, Yves, Ekim, Bilgen, Soliman, Ghada A., Carriere, Audrey, Roux, Philippe P., Ballif, Bryan A., Fingar, Diane C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804229/
https://ncbi.nlm.nih.gov/pubmed/19864431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.029637
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