Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser(863) and Multisite Phosphorylation

The rapamycin-sensitive mTOR complex 1 (mTORC1) promotes protein synthesis, cell growth, and cell proliferation in response to growth factors and nutritional cues. To elucidate the poorly defined mechanisms underlying mTORC1 regulation, we have studied the phosphorylation of raptor, an mTOR-interact...

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Hlavní autoři: Foster, Kathryn G., Acosta-Jaquez, Hugo A., Romeo, Yves, Ekim, Bilgen, Soliman, Ghada A., Carriere, Audrey, Roux, Philippe P., Ballif, Bryan A., Fingar, Diane C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804229/
https://ncbi.nlm.nih.gov/pubmed/19864431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.029637
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