Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth

UVRAG (UV radiation resistance associated) is an important regulator of mammalian macroautophagy/autophagy by interacting with BECN1, PIK3C3, and RUBCN. Phosphorylation of UVRAG by MTORC1 negatively regulates autophagosome maturation under nutrient-enriched conditions. However, how UVRAG ubiquitinat...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Autophagy
Autori principali: Feng, Xing, Jia, Yanyan, Zhang, Yuyu, Ma, Fei, Zhu, Yuekun, Hong, Xuehui, Zhou, Qingxin, He, Ruixing, Zhang, Heng, Jin, Junfei, Piao, Daxun, Huang, He, Li, Qinghua, Qiu, Xingfeng, Zhang, Zhiyong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2019
Soggetti:
Research Paper - Basic Science
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613838/
https://ncbi.nlm.nih.gov/pubmed/30686098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1570063
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