Understanding Programming of Fungal Iterative Polyketide Synthases: the Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase

Highly-reducing polyketide synthases (HR-PKSs) from fungi synthesize complex natural products using a single set of domains in a highly programmed, iterative fashion. The most enigmatic feature of HR-PKSs is how tailoring domains function selectively during different iterations of chain elongation t...

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發表在:J Am Chem Soc
Main Authors: Cacho, Ralph A., Thuss, Justin, Xu, Wei, Sanichar, Randy, Gao, Zhizeng, Nguyen, Allison, Vederas, John C., Tang, Yi
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906797/
https://ncbi.nlm.nih.gov/pubmed/26630357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b11814
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