Enzymatic Synthesis of Resorcylic Acid Lactones by Cooperation of Fungal Iterative Polyketide Synthases Involved in Hypothemycin Biosynthesis

[Image: see text] Hypothemycin is a macrolide protein kinase inhibitor from the fungus Hypomyces subiculosus. During biosynthesis, its carbon framework is assembled by two iterative polyketide synthases (PKSs), Hpm8 (highly reducing) and Hpm3 (non-reducing). These were heterologously expressed in Sa...

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Hlavní autoři: Zhou, Hui, Qiao, Kangjian, Gao, Zhizeng, Meehan, Michael J., Li, Jesse W.-H., Zhao, Xiling, Dorrestein, Pieter C., Vederas, John C., Tang, Yi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861853/
https://ncbi.nlm.nih.gov/pubmed/20222707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja100060k
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