Classification, Prediction, and Verification of the Regioselectivity of Fungal Polyketide Synthase Product Template Domains

The fungal iterative nonreducing polyketide synthases (NRPKSs) synthesize aromatic polyketides, many of which have important biological activities. The product template domains (PT) embedded in the multidomain NRPKSs mediate the regioselective cyclization of the highly reactive polyketide backbones...

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Autors principals: Li(然, Yanran, 李嫣), Xu(伟, Wei, 徐), Tang(奕, Yi, 唐)
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906267/
https://ncbi.nlm.nih.gov/pubmed/20479000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.128504
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