Classification, Prediction, and Verification of the Regioselectivity of Fungal Polyketide Synthase Product Template Domains

The fungal iterative nonreducing polyketide synthases (NRPKSs) synthesize aromatic polyketides, many of which have important biological activities. The product template domains (PT) embedded in the multidomain NRPKSs mediate the regioselective cyclization of the highly reactive polyketide backbones...

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Detalhes bibliográficos
Main Authors: Li(然, Yanran, 李嫣), Xu(伟, Wei, 徐), Tang(奕, Yi, 唐)
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906267/
https://ncbi.nlm.nih.gov/pubmed/20479000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.128504
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