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Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases

Bacterial aromatic polyketides such as tetracycline and doxorubicin are a medicinally important class of natural products produced as secondary metabolites by actinomyces bacteria. Their backbones are derived from malonyl-CoA units by polyketide synthases (PKSs). The nascent polyketide chain is synt...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Tang, Yi, Lee, Taek Soon, Khosla, Chaitan
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2004
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC340942/
https://ncbi.nlm.nih.gov/pubmed/14966533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0020031
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