Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases

Bacterial aromatic polyketides such as tetracycline and doxorubicin are a medicinally important class of natural products produced as secondary metabolites by actinomyces bacteria. Their backbones are derived from malonyl-CoA units by polyketide synthases (PKSs). The nascent polyketide chain is synt...

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Detalhes bibliográficos

Publicado no:	PLoS Biol
Principais autores:	Tang, Yi, Lee, Taek Soon, Khosla, Chaitan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	PLOS 2004
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC340942/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14966533/ https://ncbi.nlm.nih.govhttps://doi.org/10.1371/journal.pbio.0020031
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