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Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases
Bacterial aromatic polyketides such as tetracycline and doxorubicin are a medicinally important class of natural products produced as secondary metabolites by actinomyces bacteria. Their backbones are derived from malonyl-CoA units by polyketide synthases (PKSs). The nascent polyketide chain is synt...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2004
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC340942/ https://ncbi.nlm.nih.gov/pubmed/14966533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0020031 |
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