Engineering fungal non-reducing polyketide synthase by heterologous expression and domain swapping

[Image: see text] We re-annotated the A. niger NR-PKS gene, e_gw1_19.204 and its downstream R domain gene, est_GWPlus_C_190476 as a single gene which we name dtbA. Heterologous expression of dtbA in A. nidulans demonstrated that DtbA protein produces two polyketides, 2,4-dihydroxy-3,5,6-trimethylben...

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Bibliografiske detaljer
Main Authors: Yeh, Hsu-Hua, Chang, Shu-Lin, Chiang, Yi-Ming, Bruno, Kenneth S., Oakley, Berl R., Wu, Tung-Kung, Wang, Clay C. C.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681297/
https://ncbi.nlm.nih.gov/pubmed/23368695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol303328t
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