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Engineering of an “unnatural” natural product by swapping polyketide synthase domains in Aspergillus nidulans
A StcA-AfoE hybrid PKS, generated from swapping the AfoE (asperfuranone biosynthesis) SAT domain with the StcA (sterigmatocystin biosynthesis) SAT domian, produced a major new metabolite with the same chain length as the native AfoE product. Structure elucidation allowed us to propose a likely pathw...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3350771/ https://ncbi.nlm.nih.gov/pubmed/21815681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja205780g |
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