Rational Domain Swaps Reveal Insights about Chain Length Control by Ketosynthase Domains in Fungal Nonreducing Polyketide Synthases

[Image: see text] A facile genetic methodology in the filamentous fungus Aspergillus nidulans allowed exchange of the starter unit ACP transacylase (SAT) domain in the nonreduced polyketide synthase (NR-PKS) AfoE of the asperfuranone pathway with the SAT domains from 10 other NR-PKSs. The newly crea...

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Detalhes bibliográficos
Main Authors: Liu, Ting, Sanchez, James F., Chiang, Yi-Ming, Oakley, Berl R., Wang, Clay C. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993715/
https://ncbi.nlm.nih.gov/pubmed/24593241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol5003384
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