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Rational Domain Swaps Reveal Insights about Chain Length Control by Ketosynthase Domains in Fungal Nonreducing Polyketide Synthases
[Image: see text] A facile genetic methodology in the filamentous fungus Aspergillus nidulans allowed exchange of the starter unit ACP transacylase (SAT) domain in the nonreduced polyketide synthase (NR-PKS) AfoE of the asperfuranone pathway with the SAT domains from 10 other NR-PKSs. The newly crea...
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| Main Authors: | , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical
Society
2014
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3993715/ https://ncbi.nlm.nih.gov/pubmed/24593241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol5003384 |
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