Analysis of the Ketosynthase-Chain Length Factor Heterodimer from the Fredericamycin Polyketide Synthase

The pentadecaketide fredericamycin has the longest carbon chain backbone among polycyclic aromatic polyketide antibiotics whose biosynthetic genes have been sequenced. This backbone is synthesized by the bimodular fdm polyketide synthase (PKS). The initiation module is thought to synthesize a C(6) i...

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Main Authors: Szu, Ping-Hui, Govindarajan, Sridhar, Meehan, Michael J., Das, Abhirup, Nguyen, Don D., Dorrestein, Pieter C., Minshull, Jeremy, Khosla, Chaitan
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172819/
https://ncbi.nlm.nih.gov/pubmed/21867917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.07.015
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