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Roles of Conserved Active Site Residues in the Ketosynthase Domain of an Assembly Line Polyketide Synthase

Ketosynthase (KS) domains of assembly line polyketide synthases (PKSs) catalyze intermodular translocation of the growing polyketide chain as well as chain elongation via decarboxylative Claisen condensation. The mechanistic roles of ten conserved residues in the KS domain of Module 1 of the 6-deoxy...

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Bibliografiske detaljer
Udgivet i:Biochemistry
Main Authors: Robbins, Thomas, Kapilivsky, Joshuah, Cane, David E., Khosla, Chaitan
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5055053/
https://ncbi.nlm.nih.gov/pubmed/27441852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00639
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