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Roles of Conserved Active Site Residues in the Ketosynthase Domain of an Assembly Line Polyketide Synthase
Ketosynthase (KS) domains of assembly line polyketide synthases (PKSs) catalyze intermodular translocation of the growing polyketide chain as well as chain elongation via decarboxylative Claisen condensation. The mechanistic roles of ten conserved residues in the KS domain of Module 1 of the 6-deoxy...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5055053/ https://ncbi.nlm.nih.gov/pubmed/27441852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00639 |
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