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Roles of Conserved Active Site Residues in the Ketosynthase Domain of an Assembly Line Polyketide Synthase
Ketosynthase (KS) domains of assembly line polyketide synthases (PKSs) catalyze intermodular translocation of the growing polyketide chain as well as chain elongation via decarboxylative Claisen condensation. The mechanistic roles of ten conserved residues in the KS domain of Module 1 of the 6-deoxy...
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| Опубликовано в: : | Biochemistry |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5055053/ https://ncbi.nlm.nih.gov/pubmed/27441852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00639 |
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