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Assembly Line Polyketide Synthases: Mechanistic Insights and Unsolved Problems

[Image: see text] Two hallmarks of assembly line polyketide synthases have motivated an interest in these unusual multienzyme systems, their stereospecificity and their capacity for directional biosynthesis. In this review, we summarize the state of knowledge regarding the mechanistic origins of the...

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Detalhes bibliográficos
Main Authors: Khosla, Chaitan, Herschlag, Daniel, Cane, David E., Walsh, Christopher T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020578/
https://ncbi.nlm.nih.gov/pubmed/24779441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500290t
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