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In vivo and In vitro Analysis of the Hedamycin Polyketide Synthase
Hedamycin is an antitumor polyketide antibiotic with unusual biosynthetic features. Earlier sequence analysis of the hedamycin biosynthetic gene cluster implied a role for type I as well as type II polyketide synthases (PKSs). We demonstrate that the hedamycin minimal PKS can synthesize a dodecaketi...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2795786/ https://ncbi.nlm.nih.gov/pubmed/19942143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.11.005 |
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