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In vivo and In vitro Analysis of the Hedamycin Polyketide Synthase

Hedamycin is an antitumor polyketide antibiotic with unusual biosynthetic features. Earlier sequence analysis of the hedamycin biosynthetic gene cluster implied a role for type I as well as type II polyketide synthases (PKSs). We demonstrate that the hedamycin minimal PKS can synthesize a dodecaketi...

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Main Authors: Das, Abhirup, Khosla, Chaitan
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795786/
https://ncbi.nlm.nih.gov/pubmed/19942143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.11.005
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