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Mechanism and engineering of polyketide chain initiation in fredericamycin biosynthesis
The ability to incorporate atypical primer units through the use of dedicated initiation polyketide synthase (PKS) modules offers opportunities to expand molecular diversity of polyketide natural products. Here we identify the initiation PKS module responsible for hexadienyl priming of the antibioti...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2904946/ https://ncbi.nlm.nih.gov/pubmed/20540492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja102517q |
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