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Understanding Programming of Fungal Iterative Polyketide Synthases: the Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase
Highly-reducing polyketide synthases (HR-PKSs) from fungi synthesize complex natural products using a single set of domains in a highly programmed, iterative fashion. The most enigmatic feature of HR-PKSs is how tailoring domains function selectively during different iterations of chain elongation t...
Shranjeno v:
| izdano v: | J Am Chem Soc |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4906797/ https://ncbi.nlm.nih.gov/pubmed/26630357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b11814 |
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