Development of GABA(A) Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments

Recent studies have demonstrated that subtype-selective GABA(A) receptor modulators are able to relax pre-contracted human airway smooth muscle ex vivo and reduce airway hyper-responsiveness in mice upon aerosol administration. Our goal in this study was to investigate systemic administration of sub...

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Pubblicato in:Mol Pharm
Autori principali: Forkuo, Gloria S., Guthrie, Margaret L., Yuan, Nina Y., Nieman, Amanda N., Kodali, Revathi, Jahan, Rajwana, Stephen, Michael R., Yocum, Gene T., Treven, Marco, Poe, Michael M., Li, Guanguan, Yu, Olivia B., Hartzler, Benjamin D., Zahn, Nicolas M., Ernst, Margot, Emala, Charles W., Stafford, Douglas C., Cook, James M., Arnold, Leggy A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899155/
https://ncbi.nlm.nih.gov/pubmed/27120014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.6b00159
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