Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide

BACKGROUND: Glioma stem cells (GSCs) from human glioblastomas (GBMs) are resistant to radiation and chemotherapy and may drive recurrence. Treatment efficacy may depend on GSCs, expression of DNA repair enzymes such as methylguanine methyltransferase (MGMT), or transcriptome subtype. METHODS: To mod...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Schmid, Ralf S., Simon, Jeremy M., Vitucci, Mark, McNeill, Robert S., Bash, Ryan E., Werneke, Andrea M., Huey, Lauren, White, Kristen K., Ewend, Matthew G., Wu, Jing, Miller, C. Ryan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896545/
https://ncbi.nlm.nih.gov/pubmed/26826202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov321
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