Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide

BACKGROUND: Glioma stem cells (GSCs) from human glioblastomas (GBMs) are resistant to radiation and chemotherapy and may drive recurrence. Treatment efficacy may depend on GSCs, expression of DNA repair enzymes such as methylguanine methyltransferase (MGMT), or transcriptome subtype. METHODS: To mod...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Neuro Oncol
Autores principales: Schmid, Ralf S., Simon, Jeremy M., Vitucci, Mark, McNeill, Robert S., Bash, Ryan E., Werneke, Andrea M., Huey, Lauren, White, Kristen K., Ewend, Matthew G., Wu, Jing, Miller, C. Ryan
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
Materias:
Basic and Translational Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896545/
https://ncbi.nlm.nih.gov/pubmed/26826202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov321
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares