Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide

BACKGROUND: Glioma stem cells (GSCs) from human glioblastomas (GBMs) are resistant to radiation and chemotherapy and may drive recurrence. Treatment efficacy may depend on GSCs, expression of DNA repair enzymes such as methylguanine methyltransferase (MGMT), or transcriptome subtype. METHODS: To mod...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Neuro Oncol
Hlavní autoři: Schmid, Ralf S., Simon, Jeremy M., Vitucci, Mark, McNeill, Robert S., Bash, Ryan E., Werneke, Andrea M., Huey, Lauren, White, Kristen K., Ewend, Matthew G., Wu, Jing, Miller, C. Ryan
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896545/
https://ncbi.nlm.nih.gov/pubmed/26826202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov321
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky