Physiological restraint of Bak by Bcl-x(L) is essential for cell survival

Due to the myriad interactions between prosurvival and proapoptotic members of the Bcl-2 family of proteins, establishing the mechanisms that regulate the intrinsic apoptotic pathway has proven challenging. Mechanistic insights have primarily been gleaned from in vitro studies because genetic approa...

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Bibliografske podrobnosti
izdano v:Genes Dev
Main Authors: Lee, Erinna F., Grabow, Stephanie, Chappaz, Stephane, Dewson, Grant, Hockings, Colin, Kluck, Ruth M., Debrincat, Marlyse A., Gray, Daniel H., Witkowski, Matthew T., Evangelista, Marco, Pettikiriarachchi, Anne, Bouillet, Philippe, Lane, Rachael M., Czabotar, Peter E., Colman, Peter M., Smith, Brian J., Kile, Benjamin T., Fairlie, W. Douglas
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2016
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888843/
https://ncbi.nlm.nih.gov/pubmed/27198225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.279414.116
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