Physiological restraint of Bak by Bcl-x(L) is essential for cell survival

Due to the myriad interactions between prosurvival and proapoptotic members of the Bcl-2 family of proteins, establishing the mechanisms that regulate the intrinsic apoptotic pathway has proven challenging. Mechanistic insights have primarily been gleaned from in vitro studies because genetic approa...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Lee, Erinna F., Grabow, Stephanie, Chappaz, Stephane, Dewson, Grant, Hockings, Colin, Kluck, Ruth M., Debrincat, Marlyse A., Gray, Daniel H., Witkowski, Matthew T., Evangelista, Marco, Pettikiriarachchi, Anne, Bouillet, Philippe, Lane, Rachael M., Czabotar, Peter E., Colman, Peter M., Smith, Brian J., Kile, Benjamin T., Fairlie, W. Douglas
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888843/
https://ncbi.nlm.nih.gov/pubmed/27198225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.279414.116
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