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Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

Thiamin is essential for normal metabolism in pancreatic acinar cells (PAC) and is obtained from their microenvironment through specific plasma-membrane transporters, converted to thiamin pyrophosphate (TPP) in the cytoplasm, followed by uptake of TPP by mitochondria through the mitochondrial TPP (M...

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Bibliographische Detailangaben
Veröffentlicht in:Am J Physiol Gastrointest Liver Physiol
Hauptverfasser: Srinivasan, Padmanabhan, Thrower, Edwin C., Gorelick, Fred S., Said, Hamid M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888549/
https://ncbi.nlm.nih.gov/pubmed/26999808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00461.2015
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