Tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone initiates and enhances pancreatitis responses

Clinical studies indicate that cigarette smoking increases the risk for developing acute pancreatitis. The nicotine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a major cigarette smoke toxin. We hypothesized that NNK could sensitize to pancreatitis and examined its effects in i...

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Detalhes bibliográficos
Main Authors: Alexandre, M., Uduman, A. K., Minervini, S., Raoof, A., Shugrue, C. A., Akinbiyi, E. O., Patel, V., Shitia, M., Kolodecik, T. R., Patton, R., Gorelick, F. S., Thrower, E. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Pancreas
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468532/
https://ncbi.nlm.nih.gov/pubmed/22837343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00138.2012
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