Tobacco-specific carcinogen nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces AKT activation in head and neck epithelia

Exposure to tobacco carcinogens is causally associated with head and neck squamous cell carcinoma (HNSCC), but the underlying molecular mechanisms remain unclear. Here, we reported that AKT is activated at a higher frequency in both HNSCC tumors and the adjacent mucosa from HNSCC patients who are sm...

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Detalhes bibliográficos
Main Authors: WEBER, STEPHEN M., BORNSTEIN, SOPHIA, LI, YUEXIN, MALKOSKI, STEPHEN P., WANG, DONNA, RUSTGI, ANIL K., KULESZ-MARTIN, MOLLY F., WANG, XIAO-JING, LU, SHI-LONG
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249931/
https://ncbi.nlm.nih.gov/pubmed/21822536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2011.1149
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