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Extensive metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent lung carcinogen present in both unburned tobacco and cigarette smoke. The sum of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides, referred to as total NNAL, is an established urinary biomarker of human NNK upt...

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Bibliografische gegevens
Hoofdauteurs: Stepanov, Irina, Upadhyaya, Pramod, Carmella, Steven G., Feuer, Rachel, Jensen, Joni, Hatsukami, Dorothy K., Hecht, Stephen S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542896/
https://ncbi.nlm.nih.gov/pubmed/18628430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-07-2844
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