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Methyl DNA Phosphate Adduct Formation in Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
[Image: see text] The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a powerful lung carcinogen in animal models and is considered a causative factor for lung cancer in tobacco users. NNK is stereoselectively and reversibly metabolized to 4-(methylnitrosamino)-1...
Shranjeno v:
| izdano v: | Chem Res Toxicol |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical
Society
2017
|
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5770887/ https://ncbi.nlm.nih.gov/pubmed/29131934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.7b00281 |
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