Analysis of Pyridyloxobutyl and Pyridylhydroxybutyl DNA Adducts in Extra-hepatic Tissues of F344 Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol

The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are potent pulmonary carcinogens in rats. NNK and NNAL require metabolic activation to express their carcinogenicity. Cytochrome P450-catalyze...

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Detalhes bibliográficos
Main Authors: Zhang, Siyi, Wang, Mingyao, Villalta, Peter W., Lindgren, Bruce R., Upadhyaya, Pramod, Lao, Yanbin, Hecht, Stephen S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701567/
https://ncbi.nlm.nih.gov/pubmed/19358518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900015d
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