Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is metabolized to enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), found in the urine of virtually all people exposed to tobacco products. We assessed the carcinogenicity in male F-344 rats of (R)-NNAL (5 ppm in drinking water)...

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Detalhes bibliográficos
Publicado no:Carcinogenesis
Main Authors: Balbo, Silvia, Johnson, Charles S., Kovi, Ramesh C., James-Yi, Sandra A., O’Sullivan, M. Gerard, Wang, Mingyao, Le, Chap T., Khariwala, Samir S., Upadhyaya, Pramod, Hecht, Stephen S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Original Manuscript
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4247520/
https://ncbi.nlm.nih.gov/pubmed/25269804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu204
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