Quantitation of Pyridylhydroxybutyl-DNA Adducts in Liver and Lung of F-344 Rats Treated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol

The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent pulmonary carcinogen in rats and is believed to be one cause of lung cancer in smokers. NNK is metabolized to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) which is also a strong lung carcinogen...

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Auteurs principaux: Upadhyaya, Pramod, Kalscheuer, Stephen, Hochalter, J. Bradley, Villalta, Peter W., Hecht, Stephen S.
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575026/
https://ncbi.nlm.nih.gov/pubmed/18570389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx8001109
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