Comprehensive High-Resolution Mass Spectrometric Analysis of DNA Phosphate Adducts Formed by the Tobacco-Specific Lung Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone

[Image: see text] The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 1) is a potent lung carcinogen in laboratory animals and is believed to play a key role in the development of lung cancer in smokers. Metabolic activation of NNK leads to the formation of pyridylo...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Ma, Bin, Villalta, Peter W., Zarth, Adam T., Kotandeniya, Delshanee, Upadhyaya, Pramod, Stepanov, Irina, Hecht, Stephen S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652278/
https://ncbi.nlm.nih.gov/pubmed/26398225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.5b00318
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