Genetic variability in the metabolism of the tobacco-specific nitrosamine 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL)

Urinary metabolites of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides, termed total NNAL, have recently been shown to be good predictors of lung cancer risk, years prior to diagnosis. We...

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Autori principali: Ter-Minassian, Monica, Asomaning, Kofi, Zhao, Yang, Chen, Feng, Su, Li, Carmella, Steven G., Lin, Xihong, Hecht, Stephen S., Christiani, David C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247647/
https://ncbi.nlm.nih.gov/pubmed/21544809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.26162
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