Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states

The TREK subfamily of two-pore domain (K2P) K(+) channels exhibit polymodal gating by a wide range of physical and chemical stimuli. Crystal structures now exist for these channels in two main states referred to as the “up” and “down” conformations. However, recent studies have resulted in contradic...

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Опубликовано в: :J Gen Physiol
Главные авторы: McClenaghan, Conor, Schewe, Marcus, Aryal, Prafulla, Carpenter, Elisabeth P., Baukrowitz, Thomas, Tucker, Stephen J.
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2016
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886281/
https://ncbi.nlm.nih.gov/pubmed/27241700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611601
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