K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

TREK-2 (KCNK10/K2P10), a two-pore domain (K2P) potassium channel, is gated by polymodal stimuli such as stretch, fatty acids and pH, and by several drugs including the antidepressant fluoxetine (Prozac) and its metabolite norfluoxetine. However, the mechanisms that control channel gating are unclear...

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Publicat a:Science
Autors principals: Dong, Yin Yao, Pike, Ashley C.W., Mackenzie, Alexandra, McClenaghan, Conor, Aryal, Prafulla, Dong, Liang, Quigley, Andrew, Grieben, Mariana, Goubin, Solenne, Mukhopadhyay, Shubhashish, Ruda, Gian Filippo, Clausen, Michael V., Cao, Lishuang, Brennan, Paul E., Burgess-Brown, Nicola A., Sansom, Mark S. P., Tucker, Stephen J., Carpenter, Elisabeth P.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034649/
https://ncbi.nlm.nih.gov/pubmed/25766236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1261512
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