K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

TREK-2 (KCNK10/K2P10), a two-pore domain (K2P) potassium channel, is gated by polymodal stimuli such as stretch, fatty acids and pH, and by several drugs including the antidepressant fluoxetine (Prozac) and its metabolite norfluoxetine. However, the mechanisms that control channel gating are unclear...

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Bibliografske podrobnosti
izdano v:Science
Main Authors: Dong, Yin Yao, Pike, Ashley C.W., Mackenzie, Alexandra, McClenaghan, Conor, Aryal, Prafulla, Dong, Liang, Quigley, Andrew, Grieben, Mariana, Goubin, Solenne, Mukhopadhyay, Shubhashish, Ruda, Gian Filippo, Clausen, Michael V., Cao, Lishuang, Brennan, Paul E., Burgess-Brown, Nicola A., Sansom, Mark S. P., Tucker, Stephen J., Carpenter, Elisabeth P.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034649/
https://ncbi.nlm.nih.gov/pubmed/25766236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1261512
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