K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

TREK-2 (KCNK10/K2P10), a two-pore domain (K2P) potassium channel, is gated by polymodal stimuli such as stretch, fatty acids and pH, and by several drugs including the antidepressant fluoxetine (Prozac) and its metabolite norfluoxetine. However, the mechanisms that control channel gating are unclear...

Szczegółowa specyfikacja

Zapisane w:
Opis bibliograficzny
Wydane w:Science
Główni autorzy: Dong, Yin Yao, Pike, Ashley C.W., Mackenzie, Alexandra, McClenaghan, Conor, Aryal, Prafulla, Dong, Liang, Quigley, Andrew, Grieben, Mariana, Goubin, Solenne, Mukhopadhyay, Shubhashish, Ruda, Gian Filippo, Clausen, Michael V., Cao, Lishuang, Brennan, Paul E., Burgess-Brown, Nicola A., Sansom, Mark S. P., Tucker, Stephen J., Carpenter, Elisabeth P.
Format: Artigo
Język:Inglês
Wydane: 2015
Hasła przedmiotowe:
Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034649/
https://ncbi.nlm.nih.gov/pubmed/25766236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1261512
Etykiety: Dodaj etykietę
Nie ma etykietki, Dołącz pierwszą etykiete!

Podobne zapisy