Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel

The mechanosensitive two-pore domain (K2P) K(+) channels (TREK-1, TREK-2, and TRAAK) are important for mechanical and thermal nociception. However, the mechanisms underlying their gating by membrane stretch remain controversial. Here we use molecular dynamics simulations to examine their behavior in...

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Bibliografski detalji
Izdano u:Structure
Glavni autori: Aryal, Prafulla, Jarerattanachat, Viwan, Clausen, Michael V., Schewe, Marcus, McClenaghan, Conor, Argent, Liam, Conrad, Linus J., Dong, Yin Y., Pike, Ashley C.W., Carpenter, Elisabeth P., Baukrowitz, Thomas, Sansom, Mark S.P., Tucker, Stephen J.
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415359/
https://ncbi.nlm.nih.gov/pubmed/28392258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.03.006
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