Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel

The mechanosensitive two-pore domain (K2P) K(+) channels (TREK-1, TREK-2, and TRAAK) are important for mechanical and thermal nociception. However, the mechanisms underlying their gating by membrane stretch remain controversial. Here we use molecular dynamics simulations to examine their behavior in...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Aryal, Prafulla, Jarerattanachat, Viwan, Clausen, Michael V., Schewe, Marcus, McClenaghan, Conor, Argent, Liam, Conrad, Linus J., Dong, Yin Y., Pike, Ashley C.W., Carpenter, Elisabeth P., Baukrowitz, Thomas, Sansom, Mark S.P., Tucker, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415359/
https://ncbi.nlm.nih.gov/pubmed/28392258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.03.006
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