Φορτώνει......
Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel
The mechanosensitive two-pore domain (K2P) K(+) channels (TREK-1, TREK-2, and TRAAK) are important for mechanical and thermal nociception. However, the mechanisms underlying their gating by membrane stretch remain controversial. Here we use molecular dynamics simulations to examine their behavior in...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Structure |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Cell Press
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5415359/ https://ncbi.nlm.nih.gov/pubmed/28392258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.03.006 |
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