Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states

The TREK subfamily of two-pore domain (K2P) K(+) channels exhibit polymodal gating by a wide range of physical and chemical stimuli. Crystal structures now exist for these channels in two main states referred to as the “up” and “down” conformations. However, recent studies have resulted in contradic...

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Xehetasun bibliografikoak
Argitaratua izan da:J Gen Physiol
Egile Nagusiak: McClenaghan, Conor, Schewe, Marcus, Aryal, Prafulla, Carpenter, Elisabeth P., Baukrowitz, Thomas, Tucker, Stephen J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2016
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886281/
https://ncbi.nlm.nih.gov/pubmed/27241700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611601
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