TREK-1, a K(+) channel involved in polymodal pain perception

The TREK-1 channel is a temperature-sensitive, osmosensitive and mechano-gated K(+) channel with a regulation by Gs and Gq coupled receptors. This paper demonstrates that TREK-1 qualifies as one of the molecular sensors involved in pain perception. TREK-1 is highly expressed in small sensory neurons...

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Main Authors: Alloui, Abdelkrim, Zimmermann, Katharina, Mamet, Julien, Duprat, Fabrice, Noël, Jacques, Chemin, Jean, Guy, Nicolas, Blondeau, Nicolas, Voilley, Nicolas, Rubat-Coudert, Catherine, Borsotto, Marc, Romey, Georges, Heurteaux, Catherine, Reeh, Peter, Eschalier, Alain, Lazdunski, Michel
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1478167/
https://ncbi.nlm.nih.gov/pubmed/16675954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601116
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