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Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states

The TREK subfamily of two-pore domain (K2P) K(+) channels exhibit polymodal gating by a wide range of physical and chemical stimuli. Crystal structures now exist for these channels in two main states referred to as the “up” and “down” conformations. However, recent studies have resulted in contradic...

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Bibliografske podrobnosti
izdano v:J Gen Physiol
Main Authors: McClenaghan, Conor, Schewe, Marcus, Aryal, Prafulla, Carpenter, Elisabeth P., Baukrowitz, Thomas, Tucker, Stephen J.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886281/
https://ncbi.nlm.nih.gov/pubmed/27241700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611601
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