Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate

The TREK subfamily of two-pore domain K(+) (K2P) channels are inhibited by fluoxetine and its metabolite, norfluoxetine (NFx). Although not the principal targets of this antidepressant, TREK channel inhibition by NFx has provided important insights into the conformational changes associated with cha...

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Veröffentlicht in:J Gen Physiol
Hauptverfasser: Proks, Peter, Schewe, Marcus, Conrad, Linus J., Rao, Shanlin, Rathje, Kristin, Rödström, Karin E.J., Carpenter, Elisabeth P., Baukrowitz, Thomas, Tucker, Stephen J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155809/
https://ncbi.nlm.nih.gov/pubmed/34032848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.202012812
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