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Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate
The TREK subfamily of two-pore domain K(+) (K2P) channels are inhibited by fluoxetine and its metabolite, norfluoxetine (NFx). Although not the principal targets of this antidepressant, TREK channel inhibition by NFx has provided important insights into the conformational changes associated with cha...
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| Publicado no: | J Gen Physiol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8155809/ https://ncbi.nlm.nih.gov/pubmed/34032848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.202012812 |
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