A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila

An “invariant proline” separates the myosin S1 head from its S2 tail and is proposed to be critical for orienting S1 during its interaction with actin, a process that leads to muscle contraction. Mutation of the invariant proline to leucine (P838L) caused dominant restrictive cardiomyopathy in a ped...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Mol Biol
Κύριοι συγγραφείς: Achal, Madhulika, Trujillo, Adriana S., Melkani, Girish C., Farman, Gerrie P., Ocorr, Karen, Viswanathan, Meera C., Kaushik, Gaurav, Newhard, Christopher S., Glasheen, Bernadette M., Melkani, Anju, Suggs, Jennifer A., Moore, Jeffrey R., Swank, Douglas M., Bodmer, Rolf, Cammarato, Anthony, Bernstein, Sanford I.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2016
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884507/
https://ncbi.nlm.nih.gov/pubmed/27107639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.04.021
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