A Drosophila model of dominant inclusion body myopathy type 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects

Individuals with inclusion body myopathy type 3 (IBM3) display congenital joint contractures with early-onset muscle weakness that becomes more severe in adulthood. The disease arises from an autosomal dominant point mutation causing an E706K substitution in myosin heavy chain type IIa. We have prev...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Suggs, Jennifer A., Melkani, Girish C., Glasheen, Bernadette M., Detor, Mia M., Melkani, Anju, Marsan, Nathan P., Swank, Douglas M., Bernstein, Sanford I.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5483004/
https://ncbi.nlm.nih.gov/pubmed/28258125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.028050
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