A Drosophila model of dominant inclusion body myopathy type 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects

Individuals with inclusion body myopathy type 3 (IBM3) display congenital joint contractures with early-onset muscle weakness that becomes more severe in adulthood. The disease arises from an autosomal dominant point mutation causing an E706K substitution in myosin heavy chain type IIa. We have prev...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Dis Model Mech
Egile Nagusiak: Suggs, Jennifer A., Melkani, Girish C., Glasheen, Bernadette M., Detor, Mia M., Melkani, Anju, Marsan, Nathan P., Swank, Douglas M., Bernstein, Sanford I.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Company of Biologists Ltd 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5483004/
https://ncbi.nlm.nih.gov/pubmed/28258125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.028050
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