A Drosophila model of dominant inclusion body myopathy type 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects

Individuals with inclusion body myopathy type 3 (IBM3) display congenital joint contractures with early-onset muscle weakness that becomes more severe in adulthood. The disease arises from an autosomal dominant point mutation causing an E706K substitution in myosin heavy chain type IIa. We have prev...

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Publicado en:Dis Model Mech
Autores principales: Suggs, Jennifer A., Melkani, Girish C., Glasheen, Bernadette M., Detor, Mia M., Melkani, Anju, Marsan, Nathan P., Swank, Douglas M., Bernstein, Sanford I.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists Ltd 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5483004/
https://ncbi.nlm.nih.gov/pubmed/28258125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.028050
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